He worked at the US chip firm AMD before co-founding Nvidia. He and his wife were lab partners and married in 1985, eight years before he founded the company.
Within days, his standing as a seemingly untouchable figure at the head of the global artificial intelligence race crumbled.
After the first affair came to light, Huang admitted he had been"unfaithful"to his wife and apologised for hurting her and their children, according to the BBC.
The admissions cut against the family-man image he had worked to build, and against the closeness he kept with his children.
His exit leaves uncertainty in stock markets that lean on Nvidia, and over the future of a US company treated as a linchpin in the country's race for AI dominance over China.
Huang is probably more consequential to the spread of AI than many of its public faces, because Nvidia makes the leading microchips used to power the technology.
Firms using Nvidia's chips include Google, Meta, Amazon, Microsoft, SpaceX, Tesla, OpenAI and Anthropic.
In essence, his customer base includes some of the biggest companies on the planet, and they are spending heavily on Nvidia's products.
That intertwining means the damage felt by Nvidia, including on the stock market, could carry wider implications for other companies and the broader economy.
President Trump, as well as other leaders in the AI industry, had backed Huang to stay in his role.
Huang has a famously close relationship with Trump. It was no surprise that he sat at the top table.